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Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease.
Plain-language guide to PMID 7827298 (1995): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 7827298
- Journal
- Journal of gastroenterology and hepatology
- Year
- 1995
- Study type
- Randomized Controlled Trial
- Authors
- Mulder TP et al. (7 authors)
- DOI
- 10.1111/j.1440-1746.1994.tb01277.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Oxygen-derived free radicals may contribute to intestinal tissue damage in inflammatory bowel disease.
Since zinc is reported to be an efficient inducer of metallothionein synthesis, and probably of superoxide dismutase, the researchers evaluated the effect of oral zinc supplementation on metallothionein and superoxide dismutase levels in patients with inflammatory bowel disease.
Who Took Part
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.
What Was Measured
Oxygen-derived free radicals may contribute to intestinal tissue damage in inflammatory bowel disease.
Since zinc is reported to be an efficient inducer of metallothionein synthesis, and probably of superoxide dismutase, the researchers evaluated the effect of oral zinc supplementation on metallothionein and superoxide dismutase levels in patients with inflammatory bowel disease.
PubMed files the paper under topics including Colitis, Ulcerative, Crohn Disease, Intestinal Mucosa, Metallothionein, Superoxide Dismutase and Zinc.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 1995 (Journal of gastroenterology and hepatology), a journal based in Australia.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.