Interactions of growth hormone and parathyroid hormone in renal phosphate, calcium, and calcitriol metabolism and bone remodeling in postmenopausal women

What Was Tested

This controlled clinical trial paper looks at Parathyroid Hormone (PTH 1-84).

The mechanisms underlying the effects of recombinant human growth hormone (rhGH) on vitamin D, mineral, and bone metabolism are not known.

The researchers examined whether these effects are mediated by parathyroid hormone (PTH) by measuring renal phosphorus (P) and calcium (Ca) handling, serum calcitriol, and markers of bone turnover for 24 h before and 72 h after an infusion of hPTH(1-34) in eight healthy postmenopausal women at baseline and following short-term (1 week) and sustained (5 weeks) rhGH treatment.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, women only.

What Was Measured

The researchers examined whether these effects are mediated by parathyroid hormone (PTH) by measuring renal phosphorus (P) and calcium (Ca) handling, serum calcitriol, and markers of bone turnover for 24 h before and 72 h after an infusion of hPTH(1-34) in eight healthy postmenopausal women at baseline and following short-term (1 week) and sustained (5 weeks) rhGH treatment.

The subject headings attached to it are Adenylyl Cyclases, Biomarkers, Bone Remodeling, Calcitriol, Calcium, Enzyme Activation and Glomerular Filtration Rate.

What This Means in Plain Language

This is a controlled clinical trial of Parathyroid Hormone (PTH 1-84).

The publication is from 1994 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.