← Human Trials & Peer-Reviewed Studies
Pulsatile release of arginine vasopressin (AVP) and it's effect on response to desmopressin in enuresis
Plain-language guide to PMID 7878390 (1994): double-blind randomized controlled trial study of Vasopressin and Desmopressin in 35 children.
Key Facts
- PMID
- 7878390
- Journal
- Scandinavian journal of urology and nephrology. Supplementum
- Year
- 1994
- Study type
- Randomized Controlled Trial
- Authors
- Wood CM et al. (4 authors)
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vasopressin and Desmopressin in this randomized controlled trial publication.
To investigate whether response is related to nocturnal levels of arginine vasopressin (AVP) 35 children with enuresis, aged 8 to 14 years, had plasma AVP measurements overnight before entering a double blind randomised, placebo controlled crossover study to assess their response to evening treatment with desmopressin spray.
Why It Was Studied
A response to desmopressin spray is only seen in a proportion of children with enuresis.
Who Took Part
According to the abstract, 35 children were involved.
The age groups tagged for this paper are children and teenagers, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
The children were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.
What Was Measured
The subject headings attached to it are Administration, Inhalation, Arginine Vasopressin, Deamino Arginine Vasopressin and Enuresis.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 35 children.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1994 (Scandinavian journal of urology and nephrology. Supplementum), a journal based in England.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.