Postprandial lipoprotein lipase, insulin and gastric inhibitory polypeptide responses to test meals of different fatty acid composition: comparison of saturated, n-6 and n-3 polyunsaturated fatty acids

What Was Tested

Researchers studied GIP (Gastric Inhibitory Polypeptide) in this randomized controlled trial publication.

The present study was carried out to investigate effects of meals, rich in either saturated fatty acids (SFA), or n-6 or n-3 fatty acids, on postprandial plasma lipid and hormone concentrations as well as post-heparin plasma lipoprotein lipase (LPL) activity.

Who Took Part

PubMed indexes the participants as adults, men only.

The volunteers attended the Clinical Investigation Unit of the Royal Surrey County Hospital on three separate occasions in order to consume the meals.

Twelve male volunteers with an average age of 22.5 +/- 1.4 years (mean +/- SD), were selected from the University of Surrey student population; one subject dropped out of the study because he found the test meal unpalatable.

How the Study Was Run

The design is described as randomized and single-blind.

The participants were allocated by chance, so the GIP (Gastric Inhibitory Polypeptide) group and the comparison group should start out alike.

In this single-blind GIP (Gastric Inhibitory Polypeptide) study one party knew the assignments and the other did not.

The study was a randomized single-blind study comparing responses to three test meals.

Three meals were given in the early evening and postprandial responses were followed overnight for 11h.

The oils used to prepare each of the three test meals were: a mixed oil rich in saturated fatty acids (SFA) which mimicked the fatty acid composition of the current UK diet, corn oil, rich in n-6 fatty acids and a fish oil concentrate (MaxEPA) rich in n-3 fatty acids.

Postprandial plasma triacylglycerol (TAG), gastric inhibitory polypeptide (GIP), and insulin responses, as well as post-heparin LPL activity (measured at 12 h postprandially only) were investigated.

What Was Measured

The subject headings attached to it are Dietary Fats, Unsaturated, Eating, Fatty Acids, Fatty Acids, Omega-3, Fatty Acids, Omega-6, Fatty Acids, Unsaturated and Gastric Inhibitory Polypeptide.

What This Means in Plain Language

The paper is a randomized and single-blind study of GIP (Gastric Inhibitory Polypeptide).

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1994 (European journal of clinical nutrition), a journal based in England.

More context: the GIP (Gastric Inhibitory Polypeptide) compound page, all human trials.