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Angiotensin converting enzyme inhibition does not affect the response to exogenous angiotensin II in the human forearm
Plain-language guide to PMID 7893582 (1994): double-blind randomized controlled trial study of Angiotensin II.
Key Facts
- PMID
- 7893582
- Journal
- British journal of clinical pharmacology
- Year
- 1994
- Study type
- Randomized Controlled Trial
- Authors
- Lyons D et al. (4 authors)
- DOI
- 10.1111/j.1365-2125.1994.tb04376.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Angiotensin II in this randomized controlled trial publication.
Suppression of endogenous levels of angiotensin II by angiotensin converting enzyme inhibition, may result in up-regulation of vascular AT1 receptors.
The researchers have evaluated the effects of orally administered enalapril on angiotensin II induced vasoconstriction in the human forearm.
Who Took Part
The age groups tagged for this paper are adults.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Because people in this Angiotensin II study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Angiotensin II, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Angiotensin II could be set against what happens without it.
In the crossover set-up each of the participants took both Angiotensin II and the comparison in turn, acting as their own control.
The methods mention a period of 2 weeks.
What Was Measured
Suppression of endogenous levels of angiotensin II by angiotensin converting enzyme inhibition, may result in up-regulation of vascular AT1 receptors.
The researchers have evaluated the effects of orally administered enalapril on angiotensin II induced vasoconstriction in the human forearm.
PubMed files the paper under topics including Analysis of Variance, Angiotensin II, Blood Pressure, Enalapril, Forearm, Plethysmography and Up-Regulation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II over 2 weeks.
The publication is from 1994 (British journal of clinical pharmacology), a journal based in England.
More context: the Angiotensin II compound page, all human trials.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.