Effects of infusion of parathyroid hormone and primary hyperparathyroidism on formation and breakdown of type I collagen

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism, published as a controlled clinical trial.

The influence of chronic and acute exposure to parathyroid hormone (PTH) on formation and breakdown of type I collagen, using two recently developed radioimmunoassays for serum PICP (the carboxyterminal propeptide of type I procollagen) and serum ICTP (the carboxyterminal telopeptide of type I collagen), have been evaluated.

Fasting morning values were obtained from 18 women with primary hyperparathyroidism (HPT) and an equal number of age-matched, healthy controls.

Who Took Part

The study group was 18 women.

PubMed indexes the participants as adults, middle-aged adults, older adults and people over 80, women only.

What Was Measured

The influence of chronic and acute exposure to parathyroid hormone (PTH) on formation and breakdown of type I collagen, using two recently developed radioimmunoassays for serum PICP (the carboxyterminal propeptide of type I procollagen) and serum ICTP (the carboxyterminal telopeptide of type I collagen), have been evaluated.

Fasting morning values were obtained from 18 women with primary hyperparathyroidism (HPT) and an equal number of age-matched, healthy controls.

Topics PubMed links to this paper include Alkaline Phosphatase, Bone Resorption, Calcium, Collagen, Hydroxyproline, Hyperparathyroidism and Osteoblasts.

What This Means in Plain Language

This is a controlled clinical trial of Parathyroid Hormone (PTH 1-84) in 18 women in people with hyperparathyroidism.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1994 (Calcified tissue international), a journal based in United States.

More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.