Diuretic effect of clonidine during isoflurane, nitrous oxide, and oxygen anesthesia.

What Was Tested

The paper reports a study of Arginine Vasopressin and Clonidine, published as a randomized controlled trial.

Because clonidine, a relative selective alpha 2-agonist, inhibits the action of arginine vasopressin (AVP), the authors examined whether clonidine as an oral preanesthetic medication would induce diuresis and also would affect AVP release and its action during general anesthesia.

Who Took Part

The study group was 5 patients.

The age groups tagged for this paper are adults, both men and women.

For 5 patients of each group, plasma AVP and atrial natriuretic peptide concentrations and urine cyclic adenosine monophosphate concentrations as an index of AVP action were also assayed.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Arginine Vasopressin and who got the comparison, which limits bias.

Urine volume, urine osmolality, and amount of sodium and potassium excreted into urine were examined every hour for 3 h during minor surgery under general anesthesia with isoflurane and nitrous oxide in oxygen.

What Was Measured

PubMed files the paper under topics including Anesthesia, Inhalation, Arginine Vasopressin, Atrial Natriuretic Factor, Clonidine, Cyclic AMP, Diuresis and Diuretics.

What This Means in Plain Language

The paper is a randomized study of Arginine Vasopressin and Clonidine in 5 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1994 (Anesthesiology), a journal based in United States.

More context: the related Vasopressin library page, all human trials.