Effect of age on gastric acid, pepsin, pepsinogen group A and gastrin secretion in peptic ulcer patients.

What Was Tested

The paper reports a study, published as a clinical trial.

To verify the effect of age on gastric secretions in gastric (GU) and duodenal ulcer (DU) patients, the researchers carried out a retrospective study evaluating basal and stimulated gastric acid secretion in 427 peptic ulcer subjects aged between 12 and 73 years (GU = 74, DU = 353) in addition to studying gastric juice pepsin, serum pepsinogen group A (PGA) and gastrin in 175 patients (GU = 28, DU = 147).

All subjects were then divided into groups according to their sex and age (< 30, 30-39, 40-49, 50-59 and > 60 years).

Who Took Part

According to the abstract, 427 subjects were involved.

PubMed indexes the participants as children, teenagers, adults, middle-aged adults and older adults, both men and women.

What Was Measured

To verify the effect of age on gastric secretions in gastric (GU) and duodenal ulcer (DU) patients, the researchers carried out a retrospective study evaluating basal and stimulated gastric acid secretion in 427 peptic ulcer subjects aged between 12 and 73 years (GU = 74, DU = 353) in addition to studying gastric juice pepsin, serum pepsinogen group A (PGA) and gastrin in 175 patients (GU = 28, DU = 147).

The subject headings attached to it are Aging, Duodenal Ulcer, Gastric Acid, Gastric Mucosa, Gastrins, Pentagastrin and Pepsin A.

What This Means in Plain Language

This is a clinical trial in 427 subjects.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 1994 (Gerontology), a journal based in Switzerland.

More context: all human trials.