Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial

What Was Tested

Researchers studied Nafarelin in the context of endometriosis in this randomized controlled trial publication.

Who Took Part

According to the abstract, 36 subjects were involved.

PubMed indexes the participants as adults, women only.

Eligible for trial were women < or = 38 years old with unexplained infertility with or without chronic pelvic pain and stage III or IV endometriosis according to the American Fertility Society, revised, classification who underwent laparotomy as first surgical treatment for debulking or radical surgery of endometriotic lesions.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Nafarelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Nafarelin group a baseline to be compared against.

The timeline in the abstract includes 3 months.

Pelvic pain was assessed before first surgery and at the 12-month follow-up visit in women with pelvic pain by means of a multidimensional score system and a 10-point linear pain scale.

What Was Measured

Topics PubMed links to this paper include Endometriosis, Nafarelin, Pelvic Pain, Postoperative Care, Prognosis and Reproduction.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Nafarelin in 36 subjects in people with endometriosis over 3 months.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1994 (American journal of obstetrics and gynecology), a journal based in United States.

More context: the Nafarelin compound page, Endometriosis research.