Comparative pharmacokinetics and glucodynamics of two human insulin mixtures. 70/30 and 50/50 insulin mixtures.

What Was Tested

Researchers studied Insulin in this randomized controlled trial publication.

Who Took Part

The abstract describes 18 volunteers taking part.

The age groups tagged for this paper are adults and middle-aged adults, men only.

The researchers measured serum insulin and C-peptide concentrations through frequent blood sampling after each treatment.

The glucose clamp measurements included maximum infusion rates (Rmax) and time to Rmax (TRmax) from glucose infusion rate (GIR) documentation, as well as cumulative glucose infused during the first 4 h ((0)4Gtot) and total glucose infused (Gtot) during the study.

How the Study Was Run

The design is described as randomized and crossover.

The volunteers were allocated by chance, so the Insulin group and the comparison group should start out alike.

In the crossover set-up each of the volunteers took both Insulin and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Blood Glucose, C-Peptide, Drug Interactions, Insulin, Insulin, Isophane, Radioimmunoassay and Recombinant Proteins.

What This Means in Plain Language

The paper is a randomized and crossover study of Insulin in 18 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1994 (Diabetes care), a journal based in United States.

More context: all human trials.