Effect of right atrial appendicectomy on the release of atrial natriuretic peptide in humans

What Was Tested

This randomized controlled trial looks at ANP (Atrial Natriuretic Peptide).

The present study evaluated the effect of right atrial appendicectomy on the release of atrial natriuretic peptide (ANP) and subsequent changes in postoperative haemodynamics in 20 men undergoing coronary artery bypass graft surgery.

The right atrial appendix was removed in ten patients and saved in ten.

Who Took Part

The study group was 20 men.

PubMed indexes the participants as adults, middle-aged adults and older adults, men only.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.

Serum ANP, sodium levels and urinary sodium excretion were measured before and on days 1, 7 and 30 after surgery.

What Was Measured

The present study evaluated the effect of right atrial appendicectomy on the release of atrial natriuretic peptide (ANP) and subsequent changes in postoperative haemodynamics in 20 men undergoing coronary artery bypass graft surgery.

PubMed files the paper under topics including Atrial Natriuretic Factor, Coronary Artery Bypass, Coronary Disease, Cytoplasmic Granules, Heart Atria, Hemodynamics and Microscopy, Electron.

What This Means in Plain Language

The paper is a randomized study of ANP (Atrial Natriuretic Peptide) in 20 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1993 (Cardiovascular surgery (London, England)), a journal based in England.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.