Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm in acute myocardial infarction.

What Was Tested

This randomized controlled trial looks at Magnesium Sulfate.

To examine the effect of doubling serum magnesium concentration on the incidence of arrhythmias in patients with suspected acute myocardial infarction.

Who Took Part

The study group was 2316 patients.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

Clinical data were collected on 2316 randomised patients with suspected acute myocardial infarction.

Holter monitoring was performed in a subgroup of 70 patients and analysed in 48 patients in whom acute myocardial infarction was confirmed.

How the Study Was Run

The design is described as randomized and double-blind.

The patients were allocated by chance, so the Magnesium Sulfate group and the comparison group should start out alike.

As a double-blind Magnesium Sulfate study, the assignments were hidden from both participants and investigators until the end.

Randomised double blind clinical trial.

Coronary care unit of a teaching hospital.

What Was Measured

PubMed files the paper under topics including Arrhythmias, Cardiac, Electrocardiography, Ambulatory, Heart, Magnesium Sulfate and Myocardial Infarction.

What This Means in Plain Language

The paper is a randomized and double-blind study of Magnesium Sulfate in 2316 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1994 (British heart journal), a journal based in England.

More context: all human trials.