Atrial natriuretic peptide-cyclic GMP relationships in normal humans: effects of dietary sodium intake

What Was Tested

This randomized controlled trial looks at ANP (Atrial Natriuretic Peptide).

The present study was designed to investigate the relationships between circulating atrial natriuretic peptide, plasma and urinary cyclic GMP and sodium excretion under basal conditions and in response to changes in dietary sodium intake. 2.

Why It Was Studied

Measurements of plasma atrial natriuretic peptide and plasma and urinary (24h collections) cyclic GMP, sodium and creatinine were made in (i) 30 normotensive subjects on their normal sodium intake and (ii) 12 subjects on the 5th day of a low and on the 5th day of a high sodium intake. 3.

Who Took Part

The abstract describes 30 subjects taking part.

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.

What Was Measured

Measurements of plasma atrial natriuretic peptide and plasma and urinary (24h collections) cyclic GMP, sodium and creatinine were made in (i) 30 normotensive subjects on their normal sodium intake and (ii) 12 subjects on the 5th day of a low and on the 5th day of a high sodium intake. 3.

Topics PubMed links to this paper include Atrial Natriuretic Factor, Blood Pressure, Cross-Sectional Studies, Cyclic GMP, Diet and Sodium.

What This Means in Plain Language

The paper is a randomized study of ANP (Atrial Natriuretic Peptide) in 30 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1993 (Clinical science (London, England : 1979)), a journal based in England.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.