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Renal and hormonal effects of chronic inhibition of neutral endopeptidase (EC 3.4.24.11) in normal man.
Plain-language guide to PMID 8149689 (1993): double-blind randomized controlled trial of Angiotensin II and Phenylephrine in 10 subjects.
Key Facts
- PMID
- 8149689
- Journal
- Clinical science (London, England : 1979)
- Year
- 1993
- Study type
- Randomized Controlled Trial
- Authors
- O'Connell JE et al. (5 authors)
- DOI
- 10.1042/cs0850019
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Angiotensin II and Phenylephrine, published as a randomized controlled trial.
Candoxatril administration caused a transient natriuresis on day 1 of treatment, but this was not sustained, and cumulative sodium excretion at the end of the study was not altered by active therapy [1720 +/- 40 versus 1734 +/- 57 (placebo) mmol; means +/- SEM]; exchangeable body sodium content was similarly unchanged.
However, urinary cyclic GMP excretion was elevated throughout the active treatment phase when compared with placebo. 3.
Who Took Part
The abstract describes 10 subjects taking part.
By PubMed's age tags, the people studied were adults and middle-aged adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
Because people in this Angiotensin II study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the subjects and researchers unaware of who received Angiotensin II.
A placebo (an inactive look-alike) gave the Angiotensin II group a baseline to be compared against.
In the crossover set-up each of the subjects took both Angiotensin II and the comparison in turn, acting as their own control.
What Was Measured
PubMed files the paper under topics including Angiotensin II, Atrial Natriuretic Factor, Binding Sites, Blood Platelets, Indans, Kidney and Neprilysin.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II and Phenylephrine in 10 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1993 (Clinical science (London, England : 1979)), a journal based in England.
More context: the related Angiotensin II library page, all human trials.
Related Library Page
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.