Effects of acute cold pressor test on vagally stimulated gastric acid secretion and circulating levels of human pancreatic polypeptide and gastrin

What Was Tested

The paper reports a study of Pancreatic Polypeptide, published as a randomized controlled trial.

Twenty-eight studies were carried out on 7 healthy subjects, each one of them being evaluated on four separate occasions.

Active (4 degrees C) or control (37 degrees C) cold pressor tests were applied in random order after an interval of 15 min following completion of a vagal stimulation represented by modified sham feeding.

Who Took Part

The study group was 7 subjects.

By PubMed's age tags, the people studied were adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Because people in this Pancreatic Polypeptide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

A placebo (an inactive look-alike) gave the Pancreatic Polypeptide group a baseline to be compared against.

What Was Measured

Twenty-eight studies were carried out on 7 healthy subjects, each one of them being evaluated on four separate occasions.

Active (4 degrees C) or control (37 degrees C) cold pressor tests were applied in random order after an interval of 15 min following completion of a vagal stimulation represented by modified sham feeding.

Topics PubMed links to this paper include Blood Pressure, Cold Temperature, Gastric Acid, Gastrins, Pancreatic Polypeptide, Phentolamine and Propranolol.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Pancreatic Polypeptide in 7 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1994 (Digestion), a journal based in Switzerland.

More context: the Pancreatic Polypeptide compound page, all human trials.