Salt-sensitivity is associated with a hyperinsulinaemic and hyperglycaemic response to atrial natriuretic peptide infusion in human essential hypertension

What Was Tested

Researchers studied ANP (Atrial Natriuretic Peptide) in this randomized controlled trial publication.

Patients were classified into two groups either salt-sensitive (n = 8) or salt-resistant (n = 7).

Who Took Part

According to the abstract, 22 men were involved.

The age groups tagged for this paper are adults and middle-aged adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind and crossover study.

Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.

As a double-blind ANP (Atrial Natriuretic Peptide) study, the assignments were hidden from both participants and investigators until the end.

Each person switched between ANP (Atrial Natriuretic Peptide) and the comparison at some point, usually with a gap in between.

Plasma insulin and glucose were measured at time -60, 0, 20, 40, 60, 120, 180, 240 min.

Ten days after ANP infusion, blood pressure sensitivity to changes in dietary salt intake was assessed according to a randomized double-blind crossover protocol.

What Was Measured

Topics PubMed links to this paper include Atrial Natriuretic Factor, Blood Glucose, Blood Pressure, Heart Rate, Hyperglycemia, Hyperinsulinism and Hypertension.

What This Means in Plain Language

The paper is a randomized, double-blind and crossover study of ANP (Atrial Natriuretic Peptide) in 22 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1994 (Diabetologia), a journal based in Germany.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.