Alteration of the circadian rhythm of intact parathyroid hormone following a 96-hour fast

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.

PTH(1-84) secretion in normal male subjects follows a circadian rhythm.

The control of this rhythm is multifactorial with both neuroendocrine and chemical influences.

The aim of this study was to assess the effect of a 96-hour fast on the circadian rhythm of PTH(1-84), serum calcium, phosphate and nephrogenous cAMP (NcAMP), an index of PTH(1-84) bioactivity.

Who Took Part

PubMed indexes the participants as adults, men only.

Six healthy adult males aged between 28 and 40 years, mean 32 years.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Urine samples were obtained 4 hourly during the daytime and overnight.

PTH(1-84) was measured by an in-house immunoradiometric assay.

Serum calcium, phosphate, albumin, creatinine and urinary creatinine were measured by standard automated techniques.

Calcium was adjusted for albumin.

Plasma cAMP was estimated by a commercial method and urine cAMP by in-house radioimmunoassay and NcAMP obtained by calculation.

What Was Measured

The subject headings attached to it are Calcium, Circadian Rhythm, Cyclic AMP, Fasting, Immunoradiometric Assay, Parathyroid Hormone and Phosphates.

What This Means in Plain Language

The paper is a randomized study of Parathyroid Hormone (PTH 1-84).

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1994 (Clinical endocrinology), a journal based in England.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.