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Corticotropin-releasing hormone (CRH) is a respiratory stimulant in humans: a comparative study of human and ovine CRH
Plain-language guide to PMID 8196493 (1994): double-blind randomized controlled trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 8196493
- Journal
- Life sciences
- Year
- 1994
- Study type
- Randomized Controlled Trial
- Authors
- Nink M et al. (8 authors)
- DOI
- 10.1016/0024-3205(94)90118-x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Until now, these effects were investigated using human (h) CRH in both healthy volunteers and patients under long-term respiration.
The researchers now compared the effects of hCRH with those of ovine (o) CRH in ten healthy young males.
Who Took Part
The age groups tagged for this paper are adults, men only.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received ACTH (Corticotropin).
A placebo (an inactive look-alike) gave the ACTH (Corticotropin) group a baseline to be compared against.
Each person switched between ACTH (Corticotropin) and the comparison at some point, usually with a gap in between.
A time span of two weeks appears in the methods.
On two separate days within two weeks, ventilation and cardiac performance were measured during steady state conditions by using a computerized cardio-pulmonary exercise testing system.
What Was Measured
In particular it should be evaluated whether oCRH with its longer plasma half-life induces a more profound respiratory stimulation.
Topics PubMed links to this paper include Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone, Heart Rate, Hydrocortisone, Respiration and Sheep.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) over two weeks.
The publication is from 1994 (Life sciences), a journal based in Netherlands.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.