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Bioactivity and metabolism of C-type natriuretic peptide in normal man
Plain-language guide to PMID 8200946 (1994): single-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide) and CNP (C-Type Natriuretic Peptide).
Key Facts
- PMID
- 8200946
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1994
- Study type
- Randomized Controlled Trial
- Authors
- Hunt PJ et al. (5 authors)
- DOI
- 10.1210/jcem.78.6.8200946
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ANP (Atrial Natriuretic Peptide) and CNP (C-Type Natriuretic Peptide), published as a randomized controlled trial.
C-Type natriuretic peptide (CNP) is a recently identified member of the natriuretic peptide family with potent vasodepressor activity in experimental animals.
Specific CNP receptors and gene transcripts have been identified in human vascular tissues, but the bioactivity and metabolism of CNP in humans are unknown.
Who Took Part
By PubMed's age tags, the people studied were teenagers and adults, men only.
How the Study Was Run
In design terms this was a randomized, single-blind and placebo-controlled study.
The participants were allocated by chance, so the ANP (Atrial Natriuretic Peptide) group and the comparison group should start out alike.
Only one side, usually the participants, was kept unaware of whether ANP (Atrial Natriuretic Peptide) was given.
The comparison arm used a placebo, so changes seen with ANP (Atrial Natriuretic Peptide) could be set against what happens without it.
What Was Measured
Topics PubMed links to this paper include Adrenocorticotropic Hormone, Aldosterone, Angiotensin II, Arginine Vasopressin, Atrial Natriuretic Factor, Creatinine and Cyclic GMP.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide) and CNP (C-Type Natriuretic Peptide).
The publication is from 1994 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page and the CNP (C-Type Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compounds
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
CNP (C-Type Natriuretic Peptide): A natriuretic peptide involved in bone growth and blood vessel tone; vosoritide is an analog.
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
- ANP (Atrial Natriuretic Peptide) in the library
- CNP (C-Type Natriuretic Peptide) in the library
- Angiotensin II in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.