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The value of luteal support with progesterone in gonadotropin-induced cycles.

Plain-language guide to PMID 8224262 (1993): clinical trial of Chorionic Gonadotropin and Progesterone in 1988 patients.

Key Facts

PMID
8224262
Journal
Fertility and sterility
Year
1993
Study type
Clinical Trial
Authors
Hamilton CJ et al. (3 authors)
DOI
10.1016/s0015-0282(16)56277-3

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Chorionic Gonadotropin and Progesterone, published as a clinical trial.

To evaluate the effect of luteal support with vaginal P suppositories in hMG- and hCG-induced cycles.

Who Took Part

The abstract describes 1988 patients taking part.

PubMed indexes the participants as adults, women only.

Between March 1988 and February 1989 patients did not receive luteal support, while between March 1989 and January 1990 P was given routinely in the luteal phase.

Induction protocol and patient selection remained otherwise unchanged.

How the Study Was Run

Infertility clinic of a tertiary care hospital.

Twenty-seven patients with hypogonadotropic amenorrhea (World Health Organization [WHO] group I) (11 women with luteal support, 16 women without) and 102 patients with euprolactinemic clomiphene citrate (CC)-resistant anovulation (WHO group II) (52 women with luteal support, 50 women without).

What Was Measured

Topics PubMed links to this paper include Abortion, Spontaneous, Chorionic Gonadotropin, Corpus Luteum, Estradiol, Menotropins, Ovulation Induction and Pessaries.

What This Means in Plain Language

This is a clinical trial of Chorionic Gonadotropin and Progesterone in 1988 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1993 (Fertility and sterility), a journal based in United States.

More context: the related hCG (human chorionic gonadotropin) library page, all human trials.

Related Library Page

hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.