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Comparison of cyclic guanosine monophosphate response to infusion of atrial natriuretic peptide in young and elderly subjects
Plain-language guide to PMID 8227900 (1993): double-blind randomized controlled trial study of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 8227900
- Journal
- Journal of the American Geriatrics Society
- Year
- 1993
- Study type
- Randomized Controlled Trial
- Authors
- Tan AC et al. (5 authors)
- DOI
- 10.1111/j.1532-5415.1993.tb07309.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ANP (Atrial Natriuretic Peptide), published as a randomized controlled trial.
To compare the sensitivity to atrial natriuretic peptide (ANP) in young and elderly subjects.
Who Took Part
By PubMed's age tags, the people studied were adults and older adults, both men and women.
Eight healthy young (23 +/- 3 years, mean +/- SD) and eight healthy elderly (76 +/- 4 years) subjects recruited from the general population.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this ANP (Atrial Natriuretic Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on ANP (Atrial Natriuretic Peptide), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the ANP (Atrial Natriuretic Peptide) group a baseline to be compared against.
Double-blind, random-order, placebo-controlled study using two different rates of ANP infusion.
Plasma cyclic guanosine monophosphate (cGMP, the second messenger of ANP) levels reflecting the sensitivity of biologically active ANP receptors.
What Was Measured
PubMed files the paper under topics including Age Factors, Atrial Natriuretic Factor, Blood Pressure, Cyclic GMP, Heart Rate, Metabolic Clearance Rate and Receptors, Atrial Natriuretic Factor.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ANP (Atrial Natriuretic Peptide).
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1993 (Journal of the American Geriatrics Society), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.