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Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease.
Plain-language guide to PMID 8237806 (1993): double-blind randomized controlled trial of Magnesium Chloride in 21 patients.
Key Facts
- PMID
- 8237806
- Journal
- The American journal of cardiology
- Year
- 1993
- Study type
- Randomized Controlled Trial
- Authors
- Bashir Y et al. (7 authors)
- DOI
- 10.1016/0002-9149(93)90986-m
What This Study Did, in Plain Language
What Was Tested
Researchers studied Magnesium Chloride in this randomized controlled trial publication.
The effects of peroral magnesium supplementation were investigated in a randomized, double-blind, crossover trial involving 21 patients with stable congestive heart failure secondary to coronary artery disease.
All were receiving long-term loop diuretics, and had normal renal function, and low or normal serum magnesium concentrations.
Who Took Part
The abstract describes 21 patients taking part.
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and crossover.
The patients were allocated by chance, so the Magnesium Chloride group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on Magnesium Chloride, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Magnesium Chloride group a baseline to be compared against.
In the crossover set-up each of the patients took both Magnesium Chloride and the comparison in turn, acting as their own control.
What Was Measured
The effects of peroral magnesium supplementation were investigated in a randomized, double-blind, crossover trial involving 21 patients with stable congestive heart failure secondary to coronary artery disease.
Topics PubMed links to this paper include Analysis of Variance, Coronary Disease, Electrolytes, Heart Failure, Hemodynamics, Magnesium Chloride and Tachycardia, Ventricular.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Magnesium Chloride in 21 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1993 (The American journal of cardiology), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.