Renal concentrating capacity test by desmopressin in children: intranasal or intravenous route?

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

Intranasal administration of desmopressin (dDAVP) is frequently used to test renal concentrating capacity in children.

Why It Was Studied

A randomized sequence was used for the first intranasal or intravenous dDAVP test; the second alternate test was repeated in the same children in a time interval ranging from 1 to 3 weeks.

Who Took Part

The abstract describes 18 children taking part.

The age groups tagged for this paper are children and teenagers, both men and women.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

A randomized sequence was used for the first intranasal or intravenous dDAVP test; the second alternate test was repeated in the same children in a time interval ranging from 1 to 3 weeks.

Topics PubMed links to this paper include Deamino Arginine Vasopressin, Kidney Concentrating Ability, Kidney Diseases and Kidney Function Tests.

What This Means in Plain Language

The paper is a randomized study of Vasopressin and Desmopressin in 18 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1993 (American journal of nephrology), a journal based in Switzerland.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.