← Human Trials & Peer-Reviewed Studies
Corticotropin-releasing factor: an antireproductive hormone of the testis.
Plain-language guide to PMID 8382638 (1993): review.
Key Facts
- PMID
- 8382638
- Journal
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Year
- 1993
- Study type
- Review
- Authors
- Dufau ML et al. (3 authors)
- DOI
- 10.1096/fasebj.7.2.8382638
What This Paper Covers, in Plain Language
What It Covers
The paper reports a study, published as a review.
Corticotropin-releasing factor (CRF), the key neuropeptide in the stress cascade, has major inhibitory actions on testicular function in addition to its known antireproductive effects at the central level (inhibition of sexual behavior and LH secretion).
CRF is secreted by the Leydig cells of the testis and acts through high-affinity receptors at the Leydig cell membrane as a potent negative regulator of LH action, inhibiting gonadotropin-induced cAMP generation and androgen production.
Who the Included Studies Covered
PubMed tags the participants as men only.
What Was Measured
Corticotropin-releasing factor (CRF), the key neuropeptide in the stress cascade, has major inhibitory actions on testicular function in addition to its known antireproductive effects at the central level (inhibition of sexual behavior and LH secretion).
CRF is secreted by the Leydig cells of the testis and acts through high-affinity receptors at the Leydig cell membrane as a potent negative regulator of LH action, inhibiting gonadotropin-induced cAMP generation and androgen production.
PubMed files the paper under topics including Corticotropin-Releasing Hormone, Leydig Cells, Receptors, Corticotropin-Releasing Hormone, Receptors, Neurotransmitter, Signal Transduction and Testis.
What This Means in Plain Language
This is a review.
The publication is from 1993 (FASEB journal : official publication of the Federation of American Societies for Experimental Biology), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.