Angiotensin II and sympathetic activity in patients with congestive heart failure

What Was Tested

This controlled clinical trial paper looks at Angiotensin II.

This study was designed to determine the effects of intravenous angiotensin II infusions and the short-term effects of enalaprilat on venous plasma norepinephrine and norepinephrine spillover in patients with stable chronic congestive heart failure.

Who Took Part

According to the abstract, 2, patients were involved.

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

Eight patients received a double-blind vehicle control.

How the Study Was Run

The design is described as double-blind.

Blinding on both sides kept the patients and researchers unaware of who received Angiotensin II.

Heart rate, arterial pressure, forearm venous plasma norepinephrine, norepinephrine clearance (estimated from the clearance of tritiated norepinephrine) and norepinephrine spillover were measured after 30 min in the supine position and after 15 min each of head-up and head-down tilt.

What Was Measured

PubMed files the paper under topics including Analysis of Variance, Angiotensin II, Blood Pressure, Chronic Disease, Enalaprilat, Heart Failure and Heart Rate.

What This Means in Plain Language

The paper is a double-blind study of Angiotensin II in 2, patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1993 (Journal of the American College of Cardiology), a journal based in United States.

More context: the Angiotensin II compound page, all human trials.