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An ACTH 4-9 analog (Org 2766) and cognitive performance: high-dose efficacy and safety in dementia of the Alzheimer's type

Plain-language guide to PMID 8386005 (1993): double-blind randomized controlled trial study of ACTH (Corticotropin), dementia, alzheimer's & cognitive decline.

Key Facts

PMID
8386005
Journal
Biological psychiatry
Year
1993
Study type
Randomized Controlled Trial
Authors
Miller TP et al. (3 authors)
DOI
10.1016/0006-3223(93)90303-u

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial paper looks at ACTH (Corticotropin) in the context of dementia, alzheimer's & cognitive decline.

PubMed holds no abstract for it, so this summary is built from its title ("An ACTH 4-9 analog (Org 2766) and cognitive performance: high- efficacy and safety in dementia of the Alzheimer's type") and its index terms.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized and double-blind.

Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind ACTH (Corticotropin) study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

The subject headings attached to it are Adrenocorticotropic Hormone, Alzheimer Disease, Amino Acid Sequence, Behavior, Cognition, Molecular Sequence Data and Peptide Fragments.

What This Means in Plain Language

The paper is a randomized and double-blind study of ACTH (Corticotropin) in people with dementia, alzheimer's & cognitive decline.

The publication is from 1993 (Biological psychiatry), a journal based in United States.

More context: the ACTH (Corticotropin) compound page, Dementia, Alzheimer's & cognitive decline research.

Our Notes on the Compound

ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.