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The effects of dietary lipid modification on blood pressure, cardiovascular reactivity and sympathetic activity in man
Plain-language guide to PMID 8390511 (1993): crossover randomized controlled trial study of Angiotensin II, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 8390511
- Journal
- Journal of hypertension
- Year
- 1993
- Study type
- Randomized Controlled Trial
- Authors
- Straznicky NE et al. (4 authors)
- DOI
- 10.1097/00004872-199304000-00014
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Angiotensin II in the context of low blood pressure and orthostatic hypotension.
To examine the effect of dietary lipid modification on 24-h ambulatory blood pressure, cardiovascular reactivity and sympathetic activity in man.
Who Took Part
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
Twenty-four normal volunteers consumed either a high-fat or a low-fat diet for 2 weeks in an open, randomized, crossover study of duration 6 weeks.
Cardiovascular reactivity was assessed by measurement of blood pressure responses to incremental infusions of angiotensin II and noradrenaline, and to sympathetic reflex testing.
How the Study Was Run
The researchers set it up as a randomized and crossover study.
The participants were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
In the crossover set-up each of the participants took both Angiotensin II and the comparison in turn, acting as their own control.
The methods mention a period of 2 weeks.
Diets were isocaloric and balanced for sodium and potassium content.
Plasma noradrenaline spillover and clearance rates were estimated using [3H]-noradrenaline infusion.
What Was Measured
The subject headings attached to it are Angiotensin II, Blood Pressure, Cardiovascular Physiological Phenomena, Cardiovascular System, Dietary Fats, Fatty Acids and Heart Rate.
What This Means in Plain Language
The paper is a randomized and crossover study of Angiotensin II in people with low blood pressure and orthostatic hypotension over 2 weeks.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1993 (Journal of hypertension), a journal based in Netherlands.
More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.