Investigation in healthy volunteers to evaluate serum concentrations and urinary excretions of aluminium, magnesium, calcium and phosphate after multiple administration of hydrotalcit (Talcid) suspension.

What Was Tested

The paper reports a study of Aluminum Hydroxide, published as a randomized controlled trial.

The aim of this study was to evaluate the extent of aluminium absorption after repeated administration of Talcid suspension.

Why It Was Studied

Therefore, the serum concentrations of aluminium and the amount of urinary excreted aluminium were determined.

Who Took Part

The study group was 17 volunteers.

The age groups tagged for this paper are teenagers and adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and parallel-group.

Random assignment meant chance, not the researchers, decided who got Aluminum Hydroxide and who got the comparison, which limits bias.

Neither the volunteers nor the staff measuring them knew who was on Aluminum Hydroxide, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Aluminum Hydroxide group a baseline to be compared against.

The Aluminum Hydroxide group and the comparison group ran side by side rather than switching.

What Was Measured

The subject headings attached to it are Aluminum, Aluminum Hydroxide, Antacids, Calcium, Magnesium, Magnesium Hydroxide and Phosphates.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Aluminum Hydroxide in 17 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1993 (Bollettino chimico farmaceutico), a journal based in Italy.

More context: all human trials.