The effects of nicotine on the blood flow of the ophthalmic artery and the finger circulation.

What Was Tested

The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a controlled clinical trial.

Nicotine from cigarette smoking is known to produce hemodynamic changes.

In a pilot project a group of 18 glaucoma patients and 8 normal subjects were tested with nicotine, and another group of 11 glaucoma patients were tested with placebo.

Who Took Part

The study group was 18 patients.

The age groups tagged for this paper are middle-aged adults and older adults.

How the Study Was Run

The researchers set it up as a placebo-controlled and pilot study.

Some patients received a placebo instead of Therapeutic nicotine (patch, non-peptide), giving a reference point.

It is described as a pilot, a small early test of whether a larger Therapeutic nicotine (patch, non-peptide) study would be practical.

What Was Measured

In a pilot project a group of 18 glaucoma patients and 8 normal subjects were tested with nicotine, and another group of 11 glaucoma patients were tested with placebo.

Topics PubMed links to this paper include Analysis of Variance, Blood Flow Velocity, Chewing Gum, Fingers, Glaucoma, Glaucoma, Open-Angle and Intraocular Pressure.

What This Means in Plain Language

The paper is a placebo-controlled and pilot study of Therapeutic nicotine (patch, non-peptide) in 18 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1993 (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie), a journal based in Germany.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.