← Human Trials & Peer-Reviewed Studies
Treatment of adults with growth hormone (GH) deficiency with recombinant human GH.
Plain-language guide to PMID 8432773 (1993): double-blind controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 10 patients.
Key Facts
- PMID
- 8432773
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1993
- Study type
- Controlled Clinical Trial
- Authors
- Bengtsson BA et al. (10 authors)
- DOI
- 10.1210/jcem.76.2.8432773
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a controlled clinical trial.
The Comprehensive Psychological Rating Scale and the Symptom Check List-90 were used to assess any change in psychopathology.
Why It Was Studied
All patients received appropriate thyroid, adrenal, and gonadal replacement therapy.
One patient was withdrawn from the study because of edema and atrial fibrillation.
Who Took Part
The study group was 10 patients.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
In design terms this was a double-blind, placebo-controlled and crossover study.
Neither the patients nor the staff measuring them knew who was on Exogenous HGH, sermorelin & older GHRPs (why they're passed over), so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Exogenous HGH, sermorelin & older GHRPs (why they're passed over) could be set against what happens without it.
In the crossover set-up each of the patients took both Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison in turn, acting as their own control.
What Was Measured
Body composition was estimated with three independent methods: computed tomography, bioelectric impedance, and total body potassium combined with total body water assessments.
The subject headings attached to it are Adipose Tissue, Body Composition, Body Water, Calcium, Electric Impedance, Growth Hormone and Insulin-Like Growth Factor I.
What This Means in Plain Language
The paper is a double-blind, placebo-controlled and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 10 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1993 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.