Lack of effect of magnesium-aluminium hydroxide on the absorption of theophylline given as a pH-dependent sustained release preparation.

What Was Tested

The paper reports a study of Magnesium and Theophylline, published as a randomized controlled trial.

The objective of the study was to assess any change in the availability of theophylline from a sustained-release preparation (SR), induced by the coadministration with an antacid.

Why It Was Studied

The study was designed as a double-blind randomized crossover trial in the Pneumology Departments of three general hospitals.

They all had stable asthma treated with theophylline and no major organ failure or gastro-intestinal lesions requiring the use of antacids.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

Random assignment meant chance, not the researchers, decided who got Magnesium and who got the comparison, which limits bias.

As a double-blind Magnesium study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Magnesium, giving a reference point.

In the crossover set-up each of the participants took both Magnesium and the comparison in turn, acting as their own control.

What Was Measured

They all had stable asthma treated with theophylline and no major organ failure or gastro-intestinal lesions requiring the use of antacids.

PubMed files the paper under topics including Aluminum Hydroxide, Asthma, Intestinal Absorption, Magnesium and Theophylline.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium and Theophylline.

The publication is from 1993 (European journal of clinical pharmacology), a journal based in Germany.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.