A comparison of the effects of captopril and enalapril on skin responses to intradermal bradykinin and skin blood flow in the human forearm

What Was Tested

This randomized controlled trial paper looks at Bradykinin.

The effects of captopril and enalapril on skin responses to intradermal injections of bradykinin and skin blood flow in the forearm were investigated in this randomised, double-blind, placebo-controlled, cross-over study. 2.

Who Took Part

By PubMed's age tags, the people studied were adults, both men and women.

Forearm skin blood flow was measured by the technique of laser Doppler flowmetry (LDF) before the injections were made and the skin responses evaluated at 15 min after injections of bradykinin by measurement of cutaneous blood flow outside the induced weal, erythema area and weal volume. 3.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Bradykinin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Bradykinin, so expectations could not easily colour the readings.

Some participants received a placebo instead of Bradykinin, giving a reference point.

In the crossover set-up each of the participants took both Bradykinin and the comparison in turn, acting as their own control.

What Was Measured

The subject headings attached to it are Bradykinin, Captopril, Enalapril, Forearm, Laser-Doppler Flowmetry, Regional Blood Flow and Skin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Bradykinin.

The publication is from 1993 (British journal of clinical pharmacology), a journal based in England.

More context: the Bradykinin compound page, all human trials.