Blood pressure and the renin-angiotensin-aldosterone system in children receiving recombinant human growth hormone.

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.

The researchers investigated the effect of growth hormone (GH) treatment on salt and water metabolism and the renin-angiotensin-aldosterone system in children with short stature.

Who Took Part

By PubMed's age tags, the people studied were children, both men and women.

Twenty-nine short, pre-pubertal children referred to two specialist growth clinics for further assessment.

Serial measurements of blood pressure, body weight, plasma renin activity (PRA), aldosterone, electrolytes, insulin and insulin-like growth factor I (IGF-I) have been made following the initiation of GH treatment.

How the Study Was Run

In design terms this was a randomized study.

The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

What Was Measured

The subject headings attached to it are Aldosterone, Blood Pressure, Body Water, Growth Disorders, Growth Hormone, Insulin-Like Growth Factor I and Renin.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in people with low blood pressure and orthostatic hypotension.

The abstract goes on to report its results in about 12 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1993 (Clinical endocrinology), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, Low blood pressure and orthostatic hypotension research.