← Human Trials & Peer-Reviewed Studies
"Helper:" A critical events prompter for unexpected emergencies.
Plain-language guide to PMID 8576718 (1995): randomized controlled trial of Dopamine and Epinephrine in 39 subjects.
Key Facts
- PMID
- 8576718
- Journal
- Journal of clinical monitoring
- Year
- 1995
- Study type
- Randomized Controlled Trial
- Authors
- Schneider AJ et al. (5 authors)
- DOI
- 10.1007/BF01616741
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Dopamine and Epinephrine.
These recommendations are often difficult to recall, particularly in stressful emergency situations.
Using advanced cardiac life support (ACLS) protocols, the researchers built a computer-based system to exhibit precompiled response plans for medical emergencies.
To validate the usefulness of this prompting device, the researchers tested application of two of the nine ACLS algorithms, pulseless ventricular fibrillation/ventricular tachycardia (Vfib/Vtach) and bradycardia, in a simulated operating room (OR) environment.
Who Took Part
The abstract describes 39 subjects taking part.
PubMed tags the participants as both men and women.
Prior to testing their system, all 39 subjects were given time to familiarize themselves with its operation.
Subsequently, all subjects were videotaped while managing a standard simulated anesthetic.
How the Study Was Run
In design terms this was a randomized study.
The subjects were allocated by chance, so the Dopamine group and the comparison group should start out alike.
During the anesthetic, the subjects were presented with two emergency scenarios, not viewed during the familiarization period.
The electrocardiographic (EKG) signals for normal sinus rhythm, ventricular fibrillation, and second-degree heart block were presented.
By random selection, the prompter was available to half of the subjects for help with arrhythmia management (experimental group), while to half it was not (control group).
What Was Measured
PubMed files the paper under topics including Algorithms, Anesthesia, General, Anesthesiology, Anti-Arrhythmia Agents, Bradycardia, Clinical Protocols and Computer Simulation.
What This Means in Plain Language
The paper is a randomized study of Dopamine and Epinephrine in 39 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 1995 (Journal of clinical monitoring), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.