Treatment of periorbital edema with human corticotropin-releasing factor after blepharoplasty

What Was Tested

Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this randomized controlled trial publication.

The periorbital edema was measured by the use of a three-dimensional laser scanner to determine facial and eyelid volume changes as specified times postoperatively.

Why It Was Studied

This prospective study of 32 patients was undertaken to ev evaluate the formation of postoperative periorbital edema after administration of human corticotropin-releasing factor (hCRF).

Who Took Part

The abstract describes 32 patients taking part.

By PubMed's age tags, the people studied were middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.

Neither the patients nor the staff measuring them knew who was on ACTH (Corticotropin), so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with ACTH (Corticotropin) could be set against what happens without it.

What Was Measured

This prospective study of 32 patients was undertaken to ev evaluate the formation of postoperative periorbital edema after administration of human corticotropin-releasing factor (hCRF).

The subject headings attached to it are Corticotropin-Releasing Hormone, Edema, Eyelids, Orbital Diseases, Postoperative Complications and Premedication.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 32 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 1996 (Journal of the American College of Surgeons), a journal based in United States.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.