← Human Trials & Peer-Reviewed Studies
Atrial natriuretic peptide and plasma renin levels in assessment of mineralocorticoid replacement in Addison's disease
Plain-language guide to PMID 8636343 (1996): randomized controlled clinical trial of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 8636343
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1996
- Study type
- Controlled Clinical Trial
- Authors
- Cohen N et al. (5 authors)
- DOI
- 10.1210/jcem.81.4.8636343
What This Study Did, in Plain Language
What Was Tested
Researchers studied ANP (Atrial Natriuretic Peptide) in this controlled clinical trial publication.
The aim of this study was to evaluate the usefulness of plasma atrial natriuretic peptide (ANP) measurements as a marker of sodium and volume status in Addison's disease.
Why It Was Studied
Assessment of mineralocorticoid replacement therapy in Addison's disease relies on clinical features and laboratory measurements, including plasma renin and potassium.
Previous studies have questioned the value of measuring the plasma renin concentration (PRC), particularly in the setting of fludrocortisone overreplacement.
Who Took Part
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
At the end of each period, blood pressure and clinical symptoms were assessed, and blood was drawn for measurement of PRC and ANP levels.
How the Study Was Run
In design terms this was a randomized and placebo-controlled study.
Because people in this ANP (Atrial Natriuretic Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
The comparison arm used a placebo, so changes seen with ANP (Atrial Natriuretic Peptide) could be set against what happens without it.
What Was Measured
Assessment of mineralocorticoid replacement therapy in Addison's disease relies on clinical features and laboratory measurements, including plasma renin and potassium.
Previous studies have questioned the value of measuring the plasma renin concentration (PRC), particularly in the setting of fludrocortisone overreplacement.
PubMed files the paper under topics including Addison Disease, Atrial Natriuretic Factor, Blood Pressure, Cortisone, Drug Monitoring, Fludrocortisone and Mineralocorticoids.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of ANP (Atrial Natriuretic Peptide).
The publication is from 1996 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.