Effect of Rennie Liquid versus Maalox Liquid on intragastric pH in a double-blind, randomized, placebo-controlled, triple cross-over study in healthy volunteers.

What Was Tested

This randomized controlled trial looks at Magnesium and Antacids.

Despite years of successful use of calcium-containing antacids in acid-related disease, allegations of gastric rebound following their intake has brought these agents into disrepute.

By assessing intragastric acidity over the 24-h period, the researchers evaluated whether antacids induce a clinically relevant acid rebound.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

Twelve healthy volunteers were assigned to a double-blind, placebo-controlled, triple cross-over comparison of placebo, Maalox Liquid, and a calcium-containing antacid, Rennie Liquid.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

Random assignment meant chance, not the researchers, decided who got Magnesium and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Magnesium.

The comparison arm used a placebo, so changes seen with Magnesium could be set against what happens without it.

In the crossover set-up each of the participants took both Magnesium and the comparison in turn, acting as their own control.

The two antacids had identical neutralizing capacity.

Special attention was given to the acidity of pre-determined postantacid time intervals during the day and night.

What Was Measured

PubMed files the paper under topics including Aluminum Hydroxide, Analysis of Variance, Antacids, Calcium Carbonate, Carbonates, Drug Combinations and Gastric Acidity Determination.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium and Antacids.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 1996 (The American journal of gastroenterology), a journal based in United States.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.