← Human Trials & Peer-Reviewed Studies
The quality of life of patients with newly diagnosed M1 prostate cancer: experience with EORTC clinical trial 30853.
Plain-language guide to PMID 8695246 (1996): randomized controlled trial of Antineoplastic Combined Chemotherapy Protocols in 63 patients.
Key Facts
- PMID
- 8695246
- Journal
- European journal of cancer (Oxford, England : 1990)
- Year
- 1996
- Study type
- Randomized Controlled Trial
- Authors
- da Silva FC et al. (11 authors)
- DOI
- 10.1016/0959-8049(95)00402-5
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Antineoplastic Combined Chemotherapy Protocols, published as a randomized controlled trial.
At pretreatment and during the follow-up period, patients were asked to complete a questionnaire assessing their physical and psychosocial functioning, and their symptom levels.
Physicians rated the patients' performance status, pain, urological symptoms and erectile function.
Who Took Part
The abstract describes 63 patients taking part.
PubMed indexes the participants as middle-aged adults, older adults and people over 80, men only.
Assessment of QoL was included as an optimal component of EORTC protocol 30853, a phase III trial comparing LH-RH (luteinising hormone-releasing hormone) analogue combined with a non-steroidal anti-androgen versus orchiectomy in patients with M1 prostate cancer.
Due to its optional nature, only a minority of the patients in the trial were recruited for the QoL investigation. 63 patients completed a pretreatment questionnaire, of whom 49 completed a second questionnaire at least once during the initial 15 month follow-up period.
How the Study Was Run
The design is described as randomized.
Random assignment meant chance, not the researchers, decided who got Antineoplastic Combined Chemotherapy Protocols and who got the comparison, which limits bias.
What Was Measured
At pretreatment and during the follow-up period, patients were asked to complete a questionnaire assessing their physical and psychosocial functioning, and their symptom levels.
The subject headings attached to it are Antineoplastic Combined Chemotherapy Protocols, Flutamide, Goserelin, Medical Staff, Hospital, Orchiectomy, Patient Compliance and Prostatic Neoplasms.
What This Means in Plain Language
The paper is a randomized study of Antineoplastic Combined Chemotherapy Protocols in 63 patients.
The publication is from 1996 (European journal of cancer (Oxford, England : 1990)), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.