Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients

What Was Tested

This randomized controlled trial paper looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Hexarelin in the context of hyperparathyroidism.

The researchers have therefore evaluated the effect of hexarelin on PRL and GH secretion in patients with active acromegaly or pathological hyperprolactinaemia.

Who Took Part

The abstract describes 6 patients taking part.

By PubMed's age tags, the people studied were teenagers, adults, middle-aged adults and older adults, both men and women.

Basal IGF-I was measured in all subjects using an RIA following acid-ethanol extraction.

How the Study Was Run

The design is described as randomized and placebo-controlled.

The patients were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

A placebo (an inactive look-alike) gave the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group a baseline to be compared against.

GH and PRL levels were evaluated every 15 minutes for 2 hours after hexarelin or placebo.

Both hormones were measured using commercial IRMA kits.

What Was Measured

PubMed files the paper under topics including Acromegaly, Growth Hormone, Growth Substances, Hormones, Hyperprolactinemia, Oligopeptides and Prolactin.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and Hexarelin in 6 patients in people with hyperparathyroidism.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1996 (Clinical endocrinology), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the Hexarelin compound page, Hyperparathyroidism research.