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Nicotine effects on adults with attention-deficit/hyperactivity disorder.
Plain-language guide to PMID 8741955 (1996): double-blind randomized controlled trial of Therapeutic nicotine (patch, non-peptide).
Key Facts
- PMID
- 8741955
- Journal
- Psychopharmacology
- Year
- 1996
- Study type
- Randomized Controlled Trial
- Authors
- Levin ED et al. (8 authors)
- DOI
- 10.1007/BF02246281
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.
The current study was an acute, placebo-controlled double-blind experiment to determine whether nicotine might be useful as an alternative treatment of adults with ADHD symptomatology.
Why It Was Studied
Six smokers and 11 nonsmokers who were outpatient referrals for ADHD were diagnosed by DSM-IV criteria.
Measures of treatment effect included the Clinical Global Impressions (CGI) scale, Hopkins' symptom check list (SCL-90-R), the Profile of Mood States (POMS), Conners' computerized Continuous Performance Test (CPT), the Stroop test, and an interval-timing task.
Who Took Part
The age groups tagged for this paper are adults and middle-aged adults.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Therapeutic nicotine (patch, non-peptide) and who got the comparison, which limits bias.
As a double-blind Therapeutic nicotine (patch, non-peptide) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.
Active and placebo patches were given in a counter-balanced order approximately 1 week apart.
What Was Measured
Measures of treatment effect included the Clinical Global Impressions (CGI) scale, Hopkins' symptom check list (SCL-90-R), the Profile of Mood States (POMS), Conners' computerized Continuous Performance Test (CPT), the Stroop test, and an interval-timing task.
The subject headings attached to it are Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Nicotine, Psychiatric Status Rating Scales, Reaction Time, Smoking and Surveys and Questionnaires.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).
The publication is from 1996 (Psychopharmacology), a journal based in Germany.
More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.