Comparison of the effects of ranitidine effervescent tablets and magnesium hydroxide-aluminium oxide on intragastric acidity. A single-centre, randomised, open cross-over study.

What Was Tested

Researchers studied Magnesium Hydroxide and Ranitidine in this randomized controlled trial publication.

After an overnight fast, intragastric pH was monitored for 7 h using a glass electrode and a digital data recorder.

The time in % during which the pH was > or = 3.5 and the area under the curve of the obtained pH-curves were compared.

Who Took Part

The study group was 24 subjects.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and crossover study.

Because people in this Magnesium Hydroxide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The comparison arm used a placebo, so changes seen with Magnesium Hydroxide could be set against what happens without it.

Each person switched between Magnesium Hydroxide and the comparison at some point, usually with a gap in between.

What Was Measured

PubMed files the paper under topics including Aluminum Hydroxide, Antacids, Drug Combinations, Gastric Acid, Gastric Acidity Determination, Histamine H2 Antagonists and Magnesium Hydroxide.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Magnesium Hydroxide and Ranitidine in 24 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1996 (Arzneimittel-Forschung), a journal based in Germany.

More context: all human trials.