Renal effects of angiotensin I-receptor blockade and angiotensin convertase inhibition in man.

What Was Tested

Researchers studied Enalapril in this randomized controlled trial publication.

The objective was to compare two means of inhibition of the renin-angiotensin system [angiotensin-converting enzyme inhibition and selective antagonism of angiotensin II subtype 1 (AT1) receptor] on renal function in 10 healthy normotensive volunteers on a normal sodium diet.

To examine further the determinants of glomerular filtration at the microcirculation level, fractional clearance of neutral dextran was determined and sieving curves were applied on a hydrodynamic model of ultrafiltration. 4.

Why It Was Studied

The methods included measurements of hormones (plasma renin activity, plasma aldosterone), blood pressure and renal function from 45 to 135 min after administration of placebo or enalapril, and from 45 to 135 min after losartan and placebo or losartan and enalapril.

Who Took Part

The study group was 10 volunteers.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Enalapril and who got the comparison, which limits bias.

As a double-blind Enalapril study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Enalapril could be set against what happens without it.

What Was Measured

The methods included measurements of hormones (plasma renin activity, plasma aldosterone), blood pressure and renal function from 45 to 135 min after administration of placebo or enalapril, and from 45 to 135 min after losartan and placebo or losartan and enalapril.

Topics PubMed links to this paper include Aldosterone, Angiotensin II, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Biphenyl Compounds, Blood Pressure and Drug Synergism.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Enalapril in 10 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1996 (Clinical science (London, England : 1979)), a journal based in England.

More context: all human trials.