Effects of long-term growth hormone (GH) and triiodothyronine (T3) administration on functional hepatic nitrogen clearance in normal man.

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a randomized controlled trial.

A decline in urea excretion is seen following long-term growth hormone administration, reflecting overall protein anabolism.

These seemingly opposite effects are presumed to reflect different actions on peripheral protein metabolism.

The extent to which these hormonal systems have different direct effects on hepatic urea genesis has not been fully characterized.

Who Took Part

The age groups tagged for this paper are adults, men only.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group should start out alike.

Urea nitrogen synthesis rate was estimated hourly as urinary excretion corrected for gut hydrolysis and accumulation in body water.

The slope of the linear relationship between urea nitrogen synthesis rate and alanine concentration represents the liver function as to conversion of amino-N, and is denoted the functional hepatic nitrogen clearance.

All injections were given at 20 00 h.

What Was Measured

The subject headings attached to it are Alanine, Analysis of Variance, Blood Glucose, Drug Combinations, Fluoroimmunoassay, Growth Hormone and Insulin.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1996 (Journal of hepatology), a journal based in Netherlands.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.