COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers.

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.

The study had a double-blind, cross-over design with two experimental settings.

Entacapone had no effect on resting levels of GH, but PRL concentrations in plasma were slightly lower after entacapone than after placebo.

Who Took Part

According to the abstract, 12 volunteers were involved.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the volunteers and researchers unaware of who received Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

A placebo (an inactive look-alike) gave the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group a baseline to be compared against.

Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.

What Was Measured

Entacapone had no effect on resting levels of GH, but PRL concentrations in plasma were slightly lower after entacapone than after placebo.

PubMed files the paper under topics including Antiparkinson Agents, Catechol O-Methyltransferase Inhibitors, Catechols, Dopamine, Enzyme Inhibitors, Human Growth Hormone and Levodopa.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 12 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1996 (Journal of neural transmission (Vienna, Austria : 1996)), a journal based in Austria.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.