Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients.

What Was Tested

This randomized controlled trial looks at Magnesium and Calcium in the context of low blood pressure and orthostatic hypotension.

This was to test the effects of oral magnesium supplementation on blood pressure and sodium, potassium, calcium and magnesium intraerythrocyte concentrations.

Why It Was Studied

Concomitantly, plasma renin activity and serum aldosterone was also measured.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

Random assignment meant chance, not the researchers, decided who got Magnesium and who got the comparison, which limits bias.

As a double-blind Magnesium study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Magnesium, giving a reference point.

In the crossover set-up each of the participants took both Magnesium and the comparison in turn, acting as their own control.

What Was Measured

Concomitantly, plasma renin activity and serum aldosterone was also measured.

The subject headings attached to it are Aldosterone, Antihypertensive Agents, Blood Pressure, Brazil, Calcium, Erythrocytes and Hypertension.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium and Calcium in people with low blood pressure and orthostatic hypotension.

The publication is from 1996 (International journal of cardiology), a journal based in Netherlands.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, Low blood pressure and orthostatic hypotension research.