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Assessment of stimulated and spontaneous adrenocorticotropin secretory dynamics identifies distinct components of cortisol feedback inhibition in healthy humans
Plain-language guide to PMID 8923833 (1996): controlled clinical trial of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 8923833
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1996
- Study type
- Controlled Clinical Trial
- Authors
- Dorin RI et al. (6 authors)
- DOI
- 10.1210/jcem.81.11.8923833
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone), published as a controlled clinical trial.
Although exogenous CRH provides a useful assessment of corticotroph function, the suprapituitary component of ACTH regulation has been difficult to assess in humans.
The researchers sought to examine the inhibitory effects of corticosteroids on kinetic parameters of ACTH secretion, assessed by a deconvolution method, in healthy human subjects.
Plasma ACTH and serum cortisol were assessed at frequent (every 10 min) intervals during CRH/NAL or placebo infusions (1800-2100 h) on all 3 study days, and deconvolution analysis was performed to determine kinetic parameters of endogenous and stimulated ACTH secretion.
Why It Was Studied
Corticosteroids inhibit ACTH secretion through diverse cellular mechanisms, including direct pituitary and indirect suprapituitary effects.
The researchers also sought to directly compare the ACTH responses to serial administration of human CRH and NAL as well as spontaneously occurring ACTH pulses to distinguish pituitary and suprapituitary components of hypothalamic-pituitary-adrenal regulation.
Who Took Part
By PubMed's age tags, the people studied were adults, both men and women.
How the Study Was Run
In design terms this was a placebo-controlled study.
Some participants received a placebo instead of ACTH (Corticotropin), giving a reference point.
What Was Measured
PubMed files the paper under topics including Adrenocorticotropic Hormone, Corticotropin-Releasing Hormone, Feedback, Hydrocortisone, Hypothalamo-Hypophyseal System, Metyrapone and Naloxone.
What This Means in Plain Language
The paper is a placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
The publication is from 1996 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.