Restoration of growth hormone (GH) response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty acids.

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The aim of this study was to evaluate the possible role of FFA in GH release in obese and elderly subjects.

Why It Was Studied

Obesity and old age are characterized by a blunted GH response to several stimuli, including GHRH; reports also indicate high plasma FFA levels in obesity and sometimes in the elderly.

Blood glucose levels were not different in the three groups of subjects after either placebo or acipimox.

Who Took Part

According to the abstract, 50 subjects were involved.

By PubMed's age tags, the people studied were adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, single-blind, placebo-controlled and crossover study.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the subjects, was kept unaware of whether Exogenous HGH, sermorelin & older GHRPs (why they're passed over) was given.

Some subjects received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.

In the crossover set-up each of the subjects took both Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison in turn, acting as their own control.

What Was Measured

Obesity and old age are characterized by a blunted GH response to several stimuli, including GHRH; reports also indicate high plasma FFA levels in obesity and sometimes in the elderly.

Blood glucose levels were not different in the three groups of subjects after either placebo or acipimox.

Topics PubMed links to this paper include Aging, Blood Glucose, Fatty Acids, Nonesterified, Gonadotropin-Releasing Hormone, Human Growth Hormone, Hypolipidemic Agents and Insulin.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 50 subjects.

The publication is from 1996 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.