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The effect of growth hormone on low-density lipoprotein cholesterol and lipoprotein (a) levels in familial hypercholesterolemia.
Plain-language guide to PMID 8931648 (1996): double-blind randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 16 subjects.
Key Facts
- PMID
- 8931648
- Journal
- Metabolism: clinical and experimental
- Year
- 1996
- Study type
- Randomized Controlled Trial
- Authors
- Tonstad S et al. (7 authors)
- DOI
- 10.1016/s0026-0495(96)90124-9
What This Study Did, in Plain Language
What Was Tested
Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.
Severe elevations of low-density lipoprotein (LDL) cholesterol are not always normalized with conventional drugs.
The researchers investigated the effect of growth hormone in familial hypercholesterolemia (FH) in a randomized, double-blind, placebo-controlled study.
Who Took Part
The abstract describes 16 subjects taking part.
By PubMed's age tags, the people studied were adults and middle-aged adults, men only.
How the Study Was Run
In design terms this was a randomized, double-blind, single-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
In this single-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study one party knew the assignments and the other did not.
Some subjects received a placebo instead of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), giving a reference point.
What Was Measured
Baseline lipid levels were similar in both groups.
Topics PubMed links to this paper include Blood Glucose, Cholesterol, LDL, Growth Hormone, Hyperlipoproteinemia Type II, Insulin-Like Growth Factor I and Lipoprotein(a).
What This Means in Plain Language
The paper is a randomized, double-blind and single-blind study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 16 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1996 (Metabolism: clinical and experimental), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.