A double-blind comparison of nafarelin and leuprolide acetate for down-regulation in IVF cycles

What Was Tested

The paper reports a study of Leuprolide and Nafarelin, published as a randomized controlled trial.

To compare nafarelin (NAF) with leuprolide acetate (LA) for pituitary down-regulation in IVF cycles.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Patients in a private IVF program who received both nasal spray and subcutaneous injections starting in the luteal phase prior to intended stimulation with any one route containing active drug in a randomized, prospective, double-blind study.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The participants were allocated by chance, so the Leuprolide group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Leuprolide.

Variables measured included the usual hormonal values as well as oocyte data, but not pregnancy rates, because of sample size and the heterogeneity of the study group.

What Was Measured

Topics PubMed links to this paper include Down-Regulation, Embryo Transfer, Fertilization in Vitro, Hormones, Leuprolide, Nafarelin and Pituitary Gland.

What This Means in Plain Language

The paper is a randomized and double-blind study of Leuprolide and Nafarelin.

The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 1996 (International journal of fertility and menopausal studies), a journal based in United States.

More context: the Leuprolide compound page and the Nafarelin compound page, all human trials.