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An acute intake of phosphate increases parathyroid hormone secretion and inhibits bone formation in young women
Plain-language guide to PMID 8970892 (1996): randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 10 volunteers.
Key Facts
- PMID
- 8970892
- Journal
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Year
- 1996
- Study type
- Randomized Controlled Trial
- Authors
- Kärkkäinen M et al. (2 authors)
- DOI
- 10.1002/jbmr.5650111211
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.
Calcium and bone metabolism was monitored for 24 h by measuring the concentrations of serum ionized calcium (S-iCa), urinary calcium, serum phosphate (S-P), urinary P, serum intact parathyroid hormone (PTH), serum carboxy-terminal propeptide of type I collagen (PICP), serum osteocalcin (BGP), serum carboxy-terminal telopeptide of type I collagen (ICTP), urine deoxypyridinoline (DPD) and bone-specific alkaline phosphatase activity (B-ALP).
Who Took Part
The study group was 10 volunteers.
By PubMed's age tags, the people studied were adults, women only.
How the Study Was Run
The design is described as randomized.
The volunteers were allocated by chance, so the Parathyroid Hormone (PTH 1-84) group and the comparison group should start out alike.
What Was Measured
Calcium and bone metabolism was monitored for 24 h by measuring the concentrations of serum ionized calcium (S-iCa), urinary calcium, serum phosphate (S-P), urinary P, serum intact parathyroid hormone (PTH), serum carboxy-terminal propeptide of type I collagen (PICP), serum osteocalcin (BGP), serum carboxy-terminal telopeptide of type I collagen (ICTP), urine deoxypyridinoline (DPD) and bone-specific alkaline phosphatase activity (B-ALP).
PubMed files the paper under topics including Analysis of Variance, Biomarkers, Bone Development, Bone Resorption, Bone and Bones, Calcium and Homeostasis.
What This Means in Plain Language
The paper is a randomized study of Parathyroid Hormone (PTH 1-84) in 10 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1996 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.